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An antidepressant efficacy trial enrolls 400 patients. At week 4, 380 complete (95% retention). At week 8, 320 complete (80% retention). Analysis of dropouts shows: patients with no symptom improvement by week 4 are 5 times more likely to drop out before week 8 than patients with improvement.
The observed week-8 remission rate among completers is 58%. Is this estimate biased, and in what direction?
An antidepressant efficacy trial enrolls 400 patients. At week 4, 380 complete (95% retention). At week 8, 320 complete (80% retention). Analysis of dropouts shows: patients with no symptom improvement by week 4 are 5 times more likely to drop out before week 8 than patients with improvement.
The observed week-8 remission rate among completers is 58%. Is this estimate biased, and in what direction?